2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-121467S
    Acotiamide-d6 2749427-97-0 98%
    Acotiamide-d6 is a deuterium labeled Acotiamide. Acotiamide is an orally active and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia.
    Acotiamide-d6
  • HY-121584R
    Lycoperodine-1 (Standard) 42438-90-4 98%
    Lycoperodine-1 (Standard) is the analytical standard of Lycoperodine-1. This product is intended for research and analytical applications. Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca2+ sensing receptors (CaSR).
    Lycoperodine-1 (Standard)
  • HY-121683A
    2-Hexadecenal 3163-37-9 98%
    2-Hexadecenal, a long-chain fatty aldehyde, is a byproduct of sphingolipid metabolism, involved in cytoskeletal reorganization, DNA damage, and apoptosis. 2-Hexadecenal regulates ROS production and induces apoptosis in polymorphonuclear leucocytes.
    2-Hexadecenal
  • HY-122129S
    Dotriaconta-14,17,20,23,26,29-hexaenoic acid-d6 2692624-20-5 98%
    Dotriaconta-14,17,20,23,26,29-hexaenoic acid-d6 is deuterium labeled Dotriaconta-14,17,20,23,26,29-hexaenoic acid. Very long chain polyunsaturated fatty acids (VLCPUFA) are present in retina, sperm, and brain. Though little is known of their biosynthesis or functional roles in these tissues, recent studies using the elongation of very long-chain FA-4 protein suggest a unique role for VLCPUFA in retinal development and macular degeneration. Dotriaconta-14,17,20,23,26,29-hexaenoic acid is a C32:6 VLCPUFA whose specific biological actions are largely unknown, but are thought to involve normal photoreceptor cell function in the retina.
    Dotriaconta-14,17,20,23,26,29-hexaenoic acid-d6
  • HY-122940R
    Precocene II (Standard) 644-06-4 98%
    Precocene II (Standard) is the analytical standard of Precocene II (HY-122940). This product is intended for research and analytical applications. Precocene II (Ageratochromene) is a plant larva hormone antagonists that inhibits the biosynthesis of juvenile hormone. Precocene II inhibits corpora allata function and downregulates juvenile hormone levels, while exerting multiple effects including inducing precocious metamorphosis, forming macropterous morphs, inhibiting ovarian growth, producing cytotoxicity, disrupting insect development, and causing sterility and kidney damage. Precocene II blocks normal nymphal development, causes renal tubular damage and increases blood urea nitrogen levels, and also blocks juvenile hormone biosynthesis in vitro. Precocene II undergoes oxidative metabolism catalyzed by NADPH-dependent monooxygenase to generate a variety of metabolites. Precocene II can be applied in studies related to insect growth regulation and nephrotoxicity.
    Precocene II (Standard)
  • HY-123016A
    (±)9-HODE cholesteryl ester 33783-76-5 98%
    (±)9-HODE cholesteryl ester is originally extracted from atherosclerotic lesions1 and shown to be produced by Cu2+-catalyzed oxidation of LDL.2 Later studies determined that 15-LO from rabbit reticulocytes and human monocytes were able to metabolize cholesteryl linoleate, a major component of LDL, to 9-HODE cholesteryl ester.
    (±)9-HODE cholesteryl ester
  • HY-123468A
    HA-1004 dihydrochloride 92564-08-4 98%
    HA-1004 dihydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 dihydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 dihydrochloride is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models.
    HA-1004 dihydrochloride
  • HY-123593R
    Mozavaptan hydrochloride (Standard) 138470-70-9 98%
    Mozavaptan (hydrochloride) (Standard) is the analytical standard of Mozavaptan (hydrochloride). This product is intended for research and analytical applications. Mozavaptan hydrochloride (OPC-31260 hydrochloride) is a benzazepine derivative and a potent, selective, competitive and orally active vasopressin V2 receptor antagonist with an IC50 of 14 nM. Mozavaptan hydrochloride shows ~85-fold selectivity for V2 receptor over V1 receptor (IC50 of 1.2 μM), and can antagonize the antidiuretic action of arginine vasopressin (AVP) in vivo. Mozavaptan hydrochloride has the potential for hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), and congestive heart failure treatment.
    Mozavaptan hydrochloride (Standard)
  • HY-123672S
    Lovastatin-d3 hydroxy acid sodium 1217528-38-5 98%
    Lovastatin-d3 hydroxy acid (sodium) is the deuterium labeled Lovastatin hydroxy acid sodium. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM.
    Lovastatin-d3 hydroxy acid sodium
  • HY-124073R
    Dihydrocapsiate (Standard) 205687-03-2
    Dihydrocapsiate (Standard) is the analytical standard of Dihydrocapsiate. This product is intended for research and analytical applications. Dihydrocapsiate, as a compound of capsinoid family, is an orally active TRPV1 agonist. Dihydrocapsiate can be used for the research of metabolism disease.
    Dihydrocapsiate (Standard)
  • HY-124284R
    Hexamethylene bisacetamide (Standard) 3073-59-4 98%
    Hexamethylene bisacetamide (Standard) is the analytical standard of Hexamethylene bisacetamide. This product is intended for research and analytical applications. Hexamethylene bisacetamide (HMBA) is a differentiation inducer and selective bromine domain inhibitor that can differentiate across the blood-brain barrier. Hexamethylene bisacetamide can induce tumor cell differentiation and inhibit cell proliferation, showing antitumor activity. Hexamethylene bisacetamide induces apoptosis by Notch1, Bcl-2 and p53 signaling pathways. In addition, Hexamethylene bisacetamide improves the obesity phenotype of mice.
    Hexamethylene bisacetamide (Standard)
  • HY-124422R
    Pentacosanoic acid (Standard) 506-38-7
    Pentacosanoic acid (Standard) is the analytical standard of Pentacosanoic acid. This product is intended for research and analytical applications. Pentacosanoic acid is a 25-carbon long-chain saturated fatty acid. Pentacosanoic is a conjugate acid of a pentacosanoate[1].
    Pentacosanoic acid (Standard)
  • HY-124489R
    2-Hydroxyestradiol (Standard) 362-05-0 98%
    2-Hydroxyestradiol (Standard) is the analytical standard of 2-Hydroxyestradiol. This product is intended for research and analytical applications. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity.
    2-Hydroxyestradiol (Standard)
  • HY-124950A
    (+)-Picumeterol 139423-79-3 98%
    (+)-Picumeterol is a configurations of Picumeterol (HY-124950). Picumeterol is a potent and selective β2-adrenoceptor agonist with bronchodilator and anti-bronchoconstrictor effects.
    (+)-Picumeterol
  • HY-125055A
    CD08108 1417342-67-6 98%
    CD08108 is a selective MC1R full agonist with an EC50 of 70 nM against hMC1R. CD08108 participates in the melanogenesis process. CD08108 promotes cell proliferation. CD08108 can be used in studies related to vitiligo, subcutaneous diseases and photosensitive diseases.
    CD08108
  • HY-125783R
    1-Palmitoyl-sn-glycero-3-phosphocholine (Standard) 17364-16-8 98%
    1-Palmitoyl-sn-glycero-3-phosphocholine (Standard) (16:0 Lyso PC (Standard)) is the analytical standard of 1-Palmitoyl-sn-glycero-3-phosphocholine (HY-125783). This product is intended for research and analytical applications. 1-Palmitoyl-sn-glycero-3-phosphocholine is an abundant lysophosphatidylcholine. 1-Palmitoyl-sn-glycero-3-phosphocholine exhibits proinflammatory activity. 1-Palmitoyl-sn-glycero-3-phosphocholine can be used in the study of atherosclerosis.
    1-Palmitoyl-sn-glycero-3-phosphocholine (Standard)
  • HY-125818D
    Cytidine-5'-triphosphate trisodium 54619-78-2
    Cytidine-5'-triphosphate (Cytidine triphosphate) trisodium is a monomeric raw material that can be used for nucleic acid synthesis.
    Cytidine-5'-triphosphate trisodium
  • HY-125824A
    Danuglipron tromethamine 2230198-03-3 98%
    Danuglipron (PF-06882961) tromethamine is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist. Danuglipron tromethamine has the potential for type 2 diabetes research.
    Danuglipron tromethamine
  • HY-125946R
    Latanoprost lactone diol (Standard) 145667-75-0 98%
    Latanoprost lactone diol (Standard) is the analytical standard of Latanoprost lactone diol (HY-125946). This product is intended for research and analytical applications. Latanoprost lactone diol is a small organic molecule derived from Prostaglandin F2α (HY-12956), and is a key synthetic intermediate and inactive metabolically related form of Latanoprost (HY-B0577). Latanoprost lactone diol is significantly upregulated in hypothyroid rats, and its levels can be reversed by the crude polysaccharide, lactone, and oligosaccharide components of the rhizome of Atractylodis macrocephalae. Latanoprost lactone diol can be used for research related to hypothyroidism.
    Latanoprost lactone diol (Standard)
  • HY-126041A
    (±)10(11)-EpDPA 895127-65-8 98%
    (±)10(11)-EpDPA, a docosahexaenoic acid epoxygenase metabolite, acts as a substrate for soluble epoxide hydrolase (sEH) with a Km value of 5.1 µM for human sEH.
    (±)10(11)-EpDPA
Cat. No. Product Name / Synonyms Application Reactivity